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GLP-1 is predominantly secreted by enteroendocrine L cells located in the distal ileum and colon, with food intake serving as a principal physiological stimulant
Additionally, thermosensitive nanogels and stimuli-responsive nanocarriers that respond to pH or glucose levels have been proposed for precision-controlled GLP-1 delivery, enabling intelligent drug release based on glycemic fluctuations
Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc, leading to glutathione depletion