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GLP-1 accounts for most of the incretin effect after an oral glucose load and has emerged as a viable therapeutic target for the treatment of type 2 diabetes mellitus 34

10.1007/BF02739934 105 YilmazS.OzanS.BenzerF.CanatanH

In the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) outcomes trial, adults with overweight or obesity and established cardiovascular disease but without diabetes had fewer major adverse cardiovascular events with semaglutide than with placebo 14,15

Semaglutide can be an excellent option for patients who struggle with weight loss despite diet and exercise

Severe or persistent symptoms require prompt medical assessment

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