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This guidance advised that companies should show that the risk of cardiovascular events in T2DM patients didnt increase with the use of their new antidiabetic therapies (drugs or therapeutic biologics), a proactive response to concerns about the cardiovascular safety of some diabetes medications developed previously ( accessed August 25, 2025)

L-Carnitine can help enhance metabolism by improving mitochondrial function, which increases cellular energy

The difference emerged during follow-up beyond six months, and no significant difference between the two drugs was established for cardiovascular disease risk, although the limited number of cardiovascular events reduced the precision of these estimates

2020;64(4):e1900797

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