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Dedicated pharmacovigilance studies in this genetically defined cohort are urgently needed

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Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4

Given the effects on human metabolism, long-term use raises questions about how these treatments may reshape metabolic function, beyond therapy duration

doi: 10.1016/S0140-6736(18)32261-X 229 GarveyWTFriasJPJastreboffAMle RouxCWSattarNAizenbergDet al