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For example, HepG2 cells exposed to 20 mM APAP for 24 h showed only a minor (8%) reduction in GSH content, a minor increase in protein adducts, no mitochondrial dysfunction and only a 2-fold increase in lactate dehydrogenase (LDH) release [142]

However, there were only eight randomised controlled trials that specifically compared carnitine(s) to placebo or no treatment and study outcomes had high heterogeneity and were derived from low-quality evidence (Table 1)

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Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial

Infection: Poor hygiene can cause local infections or, rarely, systemic ones