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Intervention that promote a healthy microbiota, such as a heathy diet rich in fiber, or probiotics, prebiotics, and even postbiotics may improve gut-barrier integrity, boost the synthesis of SCFAs, and potentially potentiate the benefit of GLP-1RAs [5, 6, 44]

Comprehensive options like Zepbound, a dual GIP/GLP-1agonist, offer enhanced results by targeting two hormonal pathways

This trial is for adults aged 18-55 with a BMI of 18-32 (Part A), and those aged 18-80 with obesity, defined as a BMI over 30 (Part B)

To facilitate a deeper understanding, the detailed conformational changes observed during the simulation in the four systems, the number of contacts, the number of drug clusters, and the average interaction energy were elaborated below

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