As with other medicines in the incretin-based drug class, the most commonly reported side effects of retatrutide in clinical trials were gastrointestinal in nature (Jastreboff et al., 2023)
Report any suspected side effects via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk) or to your prescriber
Zobel, E
What the evidence rests on Whatever brand delivers it, the pharmacology traces to the compound class: GLP-1 receptor agonists such as semaglutide, liraglutide, and dulaglutide, and GIP/GLP-1 dual agonists such as tirzepatide, which modulate appetite regulation, satiety signaling, and gastric emptying
doi: 10.1016/j.phrs.2021.105782 80 CantiniGMannucciELuconiM
The separate TRANSCEND-T2D Phase 3 program covers type 2 diabetes (TRANSCEND-T2D-1 reported topline results March 19, 2026)