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Tirzepatide targets key mechanisms involved in OSAS pathophysiology

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We utilized a novel surgical procedure in diet-induced obese (DIO)(Flynn et al., 2015) and lean(Albaugh et al., 2019) mice wherein bile is diverted from the gallbladder (GB) to the duodenum (GB-D, a sham procedure), the jejunum (GB-J), or ileum (GB-IL)

The tests for heterogeneity within designs (Q = 10.62, df = 9, p = 0.30) were not significant, suggesting consistency among the study results

This case demonstrates that even for non-cancer conditions, NICEs lower price expectations can limit access compared to the U.S