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108, 118 This is not surprising, given that the species-specific diet in mice is very different from humans who are omnivores and during much of their evolution consumed low-glycemic load diets

Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)

Carvalho M, Pontes H, Remiao F, Bastos ML, Carvalho F

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International Journal of Molecular Sciences, 21 (17)

This phenomenon is associated with increased blast counts, immunodeficiency, and increased risk of leukemic transformation (myeloid neoplasms) with poor prognosis