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Triple agonists take this strategy further by targeting GLP-1R, GIPR, and the glucagon receptor (GCGR), aiming to regulate multiple complementary metabolic pathways
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Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells
Studies now show that GLP-1s also affect inflammation, mast cells, and even longevity markers
In the STEP-1 obesity trial, semaglutide 2.4 mg weekly produced roughly 14.9% mean body-weight loss over 68 weeks ( Wilding et al., NEJM 2021 )
65 In this regard, the incretin hormones, namely GIP and GLP-1, represent key targets for the treatment of T2D and obesity, but are also known to play significant roles in bone metabolism, especially in terms of GIP
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