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Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]
doi: 10.1186/s13059-023-02931-y 46 XiongJHeJZhuJPanJLiaoWYeHet al
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A bibliometric analysis of over 2,500 publications from 2000 to 2024 highlights NLRP3 inflammasome activation and autophagy as emerging hotspots in the pathogenesis of oxidative stress-mediated diabetic retinopathy (DR)