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Because it is often in short supply, it is considered the "rate-limiting" factor

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At this concentration, each unit on a U-100 syringe equals exactly 25 mcg, or 0.025 mg

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Taken together, these results suggest that, at the doses tested in this study, MEDI4166 demonstrated insufficient GLP-1 receptor stimulation and that substantially higher doses of MEDI4166 would be required to achieve clinical efficacy in terms of glycaemic control