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Typically, dietary phenolic substances are extensively metabolized, e.g., by gut bacteria as well as by phase I and phase II reactions in enterocytes and hepatocytes (24)

232,233 GLP-1 inhibits the release of glucagon from -cells through multiple mechanisms

this finding is consistent with that of another study, that is, the activation of the MAPK pathway (e.g., ERK1/2 activation) is involved in ER stress, cell proliferation, cell cycle arrest, and autophagy 38