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In rodent studies, glycyrrhizin administration reduces reactive oxygen species (ROS) levels in liver mitochondria, indicating mitigation of mitochondrial oxidative stress ( 4 induced fibrosis models reveals that glycyrrhizin upregulates multiple members of the glutathione S-transferases family (Gstm1, Gstm2, Gsta1), which participate in glutathione metabolism and xenobiotic detoxification (Wang Q