An efficacious treatment for AD has not been forthcoming in part due to the large numbers of potentially important biomarkers, the difficulty in determining their diagnostic reliability and validity, and the multifactorial characteristics of the disease process
Nature 389 , 627631 (1997)
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The renoprotective effect of Nrf2 activation in systemic Keap1-KD mice is nicely recapitulated in a gene-modified mouse line in which the Keap1 gene is deleted exclusively in adult renal tubular cells (Table 1 and Figure 3A) [67]
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