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Osteophytes, though anatomically distinct from subchondral bone, are closely associated with its pathological changes in OA

Glutathione is the bodys master antioxidant a naturally occurring compound that fights free radical damage, regulates melanin production, and supports overall skin health

This enhanced melanin deposition occurs without a corresponding proliferation of melanocytes, distinguishing these macules from other pigmented oral pathologies

doi: 10.1146/annurev-immunol-032712-100008 139 GranatoMGilardini MontaniMSFilardiMFaggioniACironeM

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The drug is a synthetic version of a Melanocyte-stimulating-hormone (-MSH), and works by 'hacking' the body's regulation of pigment cells