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Osmolality Tonicity Assessment Nasal sprays should be formulated as isotonic solutions (270330 mOsm/kg) to minimize irritation and damage to the nasal mucociliary clearance apparatus

There is also no published stability data for the two held in a single solution

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10.1016/s0014-2999(97)01033-9 [DOI] [PubMed] [Google Scholar] Sikiric P., Seiwerth S., Mise S., Staresinic M., Bedekovic V., Zarkovic N., et al