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January 22, 2019

Published RCT data on a relevant endpoint

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Patients revert back to their former baseline(s) after stopping them, whether its gaining weight back, liver labs reverting to abnormal ranges, intracranial pressure going back up, or otherwise

The control of DPP4 shedding, which increases levels of the circulating or sDPP4 form (Figure 1), is poorly understood

One randomized controlled trial that included 56 subjects with type 2 diabetes and NAFLD found 1,000 mg omega-3 fatty acids (including 180 mg EPA and 120 mg DHA) twice daily for 12 weeks improved blood chemistries and body measurements related to NAFLD, leading to reductions in three indices used to assess NAFLD presence, but did not appear to reduce cardiovascular and metabolic risk factors