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Due to lack of a nervous system, plants have evolved sophisticated mechanisms to systemically deliver the wound signal from the site of injured organs to the distal undamaged tissues, which helps them be well-prepared for upcoming dangers 33

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They highlight that inadvertent intravascular injection, high cumulative dosing, and patient factors (extremes of age, cardiac, hepatic, or renal disease, pregnancy) are major contributors, and that bupivacaine carries the greatest cardiotoxic risk

Protective effect of hyperoside against renal ischemia-reperfusion injury via modulating mitochondrial fission, oxidative stress, and apoptosis