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doi: 10.3389/fphys.2025.1497566 46 ZhangYZhangWZhaoYPengRZhangZXuZet al

Another study in 2019 indicated that NIN reduced -SMA and Smad3 protein and mRNA levels and blocked oxidative stress, inflammation and the TGF--Smad3 and JNK-Smad3 pathways, thereby carrying out its antifibrotic effects (Hernndez-Aquino et al., 2019)

The information below is descriptive, not prescriptive

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* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies ** Based on the treatment policy estimand: estimated efficacy regardless of whether patients stayed on treatment or took other weight loss therapies About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program)

Managing hypertension: ideal targets for blood pressure, lifestyle levers, and why early pharmacology matters [18:15]