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In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions

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In addition to mTORC signaling, CUL5 promotes the ubiquitination and degradation of p62 by forming a complex with ASB6a protein containing a C-terminal SOCS box motifthereby enhancing autophagy in hepatocellular carcinoma (129)

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