Chronic stress Long-term stress increases oxidative processes in the body, leading to GSH depletion and reduced ability to neutralize harmful molecules
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Search parameters included: two allowed missed cleavages, mass tolerances of 4.5 ppm and 20 ppm for precursor and fragment ions, carbamidomethylation of cysteine as a fixed modification, acetylation of the N-terminal residue and oxidation of methionine as variable modifications, and a false discovery rate of 0.01 for both peptides and proteins
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A possible hypothesis is that aggregation is probably a consequence of oxidative modications of -synuclein [69]