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"Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes." Cardiovascular Diabetology, 2022

This is a normal physiological adjustment, not a character flaw

GLP-1 Bridge is a workaround, since it operates outside the Part D benefit, runs on CMSs demonstration authority, and expires on December 31, 2027

Shen, L., Wang, D

Treatment satisfaction in people with type 2 diabetes mellitus treated with once-weekly dulaglutide: data from the AWARD-1 and AWARD-3 clinical trials

Cagrilintide represents the modern re-engineering of that idea: a lipidated, structurally modified amylin analogue stable enough for once-weekly dosing and active at both the amylin and calcitonin receptors