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Changes in Fat-Free Mass during Significant Weight Loss: A Systematic Review. International Journal of Obesity, vol

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High PARP levels lead to the rapid consumption of the NAD + pool and, consequently, to a decrease in sirtuin levels, promoting aging

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Interventions to modulate NAD + levels Several strategies have been developed to modulate NAD + metabolism, both for mechanistic investigation purposes and to assess their potential therapeutic effects to improve health in aging or disease