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In PDAC, the overexpression of cytochrome P450 2J2 (CYP2J2) leads to elevated levels of 8,9-DHET, which upregulates FSP1 mRNA and contributes to ferroptosis resistance in PDAC

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It has also been suggested that the combination of folate, vitamin B12, and vitamin B6 may improve methylation, increase transsulfuration, and possibly reduce stress