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Hertz et al

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It was one of the rarer side effects reported in trials for semaglutide (Ozempic) and tirzepatide

Peyronies disease (PD) is caused by an inflammatory process of the penile tunica albuginea, resulting in the formation of fibrotic plaques, which may lead to penile deformity

This stimulates adenylate cyclase activity, resulting in elevated intracellular cyclic AMP levels and downstream activation of protein kinase A, which supports growth hormone related cellular responses