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GI side effects of GLP-1s may be mitigated with appropriate dose escalation when initiating therapy

The AOD-9604 provides direct daytime fat mobilization

p for interaction = 0.91) suggests a similar magnitude of benefit for the primary outcome in this trial based on presence or absence of comorbid CVD on a background of renal impairment (88)

In a Phase 2 obesity trial, participants receiving higher doses achieved up to 24.2% mean weight loss at 48 weeksone of the most impressive results reported for an investigational anti-obesity medication

Weight loss effects of GLP-1RAs Liraglutide (3.0 mg, Saxenda), a GLP-1RA that activates the GLP-1 receptor, was approved by the FDA in December 2014 for adult obesity treatment [38] and has recently shown efficacy in adolescents aged 12 to 18 years

Tirzepatide has a more favourable tolerability profile based on current data