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Over many doses, the vacuum can become strong enough to suck air into the syringe when you try to draw, giving you an inaccurate volume

The vascular effects of cocaine include angiogenesis and vasoconstriction, in contrast to heroins predisposition to ischemic and hemorrhagic complications

Worked example 2 the 30 mg vial Concentration: 30 mg 3 mL = 10 mg/mL Starting 2 mg dose: 2 mg 10 mg/mL = 0.20 mL = 20 units At 4 mg: 0.40 mL = 40 units | at 8 mg: 0.80 mL = 80 units | at 12 mg: 1.20 mL = 120 units Notice the higher-strength 30 mg build keeps every draw small the 20 mg, 24 mg and 30 mg vials all reconstitute to the same tidy 10 mg/mL, which is why they are convenient for higher maintenance doses

If a clinician pooh-poohs a request for a vitamin B12 check because an older person had a recent normal blood count, you can share this research article with the clinician

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Methemoglobin-forming agents are potent, but due to the transformation of hemoglobin into methemoglobin, they impair tissue delivery of oxygen