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If tirzepatide can reduce intracranial pressure enough to resolve headaches in IIH, it is plausible that it can reduce pressure enough to lower the migraine threshold in people without a formal IIH diagnosis

(1) Bethanechol is a direct-acting muscarinic agonist that stimulates M3 receptors on the bladder detrusor muscle to promote contraction and facilitate urination

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While occasional acid reflux (GER) is common, chronic reflux (GERD) should not be ignored