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In contrast to CFU-e, BFU-e progenitors proliferate slowly [36] and respond to stem cell factor (SCF), interleukin-3 (IL-3), IL-6, and insulin-like growth factor 1 (IGF-1) [36,37,38]

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However, it can be difficult to maintain these levels, especially as you get older, live under constant stress, or have an ongoing health problem