microdosing semaglutide for weight loss People are 'microdosing' weight-loss drugs. A GP explains what to watch out GLP-1s aren't just for weight

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Heres how I explain them to patients

Semaglutide dosing follows a carefully structured escalation protocol, and reaching the 0.75mg dose marks a significant threshold in your weight management journey

In the UK, combining Januvia (sitagliptin) and Rybelsus (semaglutide) is generally not recommended according to current clinical guidance

Bombassaro B, Araujo EP, Velloso LA (2024) The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments

The legal requirements are clear, enforcement is active and aggressive, and the consequences of non-compliance are severe.