Specifically, the production of NETs can be triggered by inorganic polyphosphate (polyP), notably also a secretory product of MCs which co-express it with CD68 [45]
Nonetheless, research focusing on their safety during pregnancy is scarce, with existing studies primarily addressing metabolic effects rather than gestational safety.224 Given that GLP-1/GIP dual agonists modulate multiple metabolic pathways, further research is necessary to elucidate their potential impact on fetal development.227 Additionally, safety assessments of GLP-1RAs and GLP-1/GIP dual agonists in non-pregnant women have identified common adverse reactions, including gastrointestinal discomfort and anorexia
Always tell your healthcare provider about all medications and supplements you're taking
Zepbound calculator | See current pricing At your first visit, your provider reviews your health history, goals, prior medication experience, and relevant clinical factors and makes a recommendation
Metformin (Glucophage) the first-line oral therapy for type 2 diabetes is also extremely common
It is important that you work with a healthcare practitioner thats well-versed in MCAS and histamine intolerance