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These in vitro mechanisms were recapitulated ex vivo, as observed by the strong correlations of ex vivo 15LO1 protein with intracellular GSH ( r = 0.68, P = 0.005) and GSH:GSSG ( r = 0.62, P = 0.014) in freshly brushed HAECs (Figure 3F)

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10.1016/S0140-6736(14)61393-3 Lancet 114 KamathA

NICE guidelines and technology appraisals including the current core obesity guideline and relevant TAs provide the framework for prescribing decisions in England

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