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no published human PK data exists for either fragment

This dual mechanism distinguishes Mounjaro from exendin-4-based therapies, offering enhanced glycaemic control and weight reduction in type 2 diabetes

Jensterle M, Janez A, Fliers E, DeVries JH, VrtacnikBokal E, Siegelaar SE

Then, the tissue was homogenized in 5 ml/gm cold buffer, which consisted of 50 mM tris-HCl, pH 7.5, 5 mM EDTA, 1 nM DTT

Nature 591 , 306311 (2021)