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Data availability Data are contained within the article as well as in the Supplementary material

Structural and biophysical studies using NMR and small-angle X-ray scattering have demonstrated that GSH directly participates in Fe-S cluster assembly, including formation of mitochondrial Fe-S biosynthetic complexes essential for respiratory chain function 204,205

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grade 24 neurotoxicity was lower with GSH (P0.0030.004)

Other significant factors include genetic variations, nutritional deficiencies of cofactors (copper, zinc, manganese), overwhelming oxidative stress, and inflammatory conditions that alter SOD expression or activity