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B12 supplementation is often beneficial, especially for those on methotrexate

Potential Side Effects and Digestive Changes The most common adverse effects of Wegovy involve the gastrointestinal system, with nausea, diarrhoea, vomiting, constipation, and abdominal pain reported in clinical trials, as detailed in the MHRA-approved SmPC

Journal of Clinical Endocrinology & Metabolism , 106(2), 388-396

Alternatively, make your timing switch first while staying at your current dose, stabilize for 2 weeks, then escalate the dose

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Common symptoms include nausea, constipation, diarrhea, bloating, and appetite suppression