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#DES #DES2026 #Diabetes #Orforglipron #DiabetesEducation #OralGLP1 #Endocrinology #DiabetesCare To view or add a comment, sign in **Is the Future of Obesity Treatment Moving from Injections to Pills?** For years, obesity management has been dominated by injectable GLP-1 receptor agonists such as semaglutide and tirzepatide

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61 GLP-1R activation triggers Gs-protein coupling, elevating cAMP, modulating calcium mobilization, and inducing -arrestin recruitment

The menopause transition is linked with real body changes: one meta-analysis found higher BMI, body fat, waist size, and visceral fat after menopause, and a newer review described the same shift toward more weight around the middle

This discomfort is a protective feature, not a sign of damage

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