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Combined sodium-glucose-transporters inhibitors and glucagon-like-peptide receptor agonist compared with monotherapy improves long-term survival: a real-world registry

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Despite this shared mechanism, the two receptors exhibit distinct expression patterns and physiological roles that are genuinely complementary: When both axes are activated concurrently, the cAMP response in pancreatic -cells exceeds that of either agonist alone, indicating synergistic rather than merely additive intracellular signaling

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