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In addition, ALOX15 can induce a series of destructive events when cells are subjected to glutamate-induced oxidative stress, including breakdown of the mitochondrial membrane potential, production of ROS, and cytochrome c release, finally leading to cell death (Pallast et al., 2009)

When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes

These compounds include pyruvate, which can be converted into acetyl-CoA and enter the tricarboxylic acid (TCA) cycle or be used for fatty acid synthesis, and -ketoglutarate, a precursor of glutamate and an intermediate of the TCA cycle

Cagrilintide and semaglutide are not competitors they are complements

Neurodegeneration represents another frontier where GHK-Cu is showing promise

We supply our peptides as lyophilised powders because it vastly increases their stability and structural integrity during transit and storage