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The main enzymatic antioxidants are catalase, GPx and SOD while reduced glutathione, vitamin C, vitamin E, carotene, ceruloplasmin and bilirubin are non-enzymatic factors [21]

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This is a potentially lethal complication of metformin therapy that typically occurs when renal dysfunction results in very high blood metformin levels, which inhibit mitochondrial function resulting in the overproduction of lactate (53)

[2] [9] Causes [edit] Angular cheilitis is thought to be a multifactorial disorder of infectious origin, [10] with many local and systemic predisposing factors

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