glutathione and free radicals oxidation reduction reaction in relation to Figure 1 from Free radicals

[Google Scholar] 125.Monirujjaman M, Bathe OF, Mazurak VC

Intense exercise creates a temporary spike in oxidative stress

In an injectable context, applying that same logic, a visibly degraded solution is a different and more serious concern, since you'd be introducing degradation products and potentially free copper ions rather than the intended complex

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But people with darker skin tones might also require an extended remedy duration, starting from 1 to a few months, to attain seen lightening