British Journal of Pharmacology , 179(4), 557570
Long-term studies also show that patients can maintain their weight loss with continued use of GLP-1 medications, especially when combined with healthy lifestyle changes
This binding triggers insulin secretion, suppresses glucagon, and signals satiety
For many adults, metabolism naturally slows, appetite hormones shift, and stress or age causes stubborn fat to linger in areas that once responded quickly
Severe constipation can increase discomfort and reduce activity
Therefore, we believe that the discovery of low-cost oral GLP-1RA analogues or synergists and the continuous elucidation of the possible mechanism of action of GLP-1 are of great significance for the expansion of the field of disease treatment