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Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38

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This 39-amino acid peptide showed structural similarity to human GLP-1, sharing approximately 53% sequence homology

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