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Curcumin can promote the dissociation of Nrf2 from Keap1 and enhance its activation to facilitate the upregulation of antioxidant enzymes and phase II detoxifying enzymes, which collectively reduce oxidative stress and strengthen cellular resilience (Rathore et al., 2023)

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For example, Papokastas and colleagues 5 found that treatment of major depressive disorder (MDD) with 15mg of Lmethylfolate in conjunction with an SSRI showed significantly greater efficacy compared to SSRI therapy alone regarding response rate and degree of change in depression symptom scores

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