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Compounds under screening were added for 1.5 hours as pretreatment and then as co-treatment with cisplatin for 22 hours

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It also stops tyrosinase production, which makes melanin

These changes were manifested by swollen vacuolated follicular cells, epithelial stratification, along with excessive vacuolation of the colloid

The approach demonstrates how peptides can be designed to target specific aspects of lupus autoimmunity rather than the immune system as a whole