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The missing piece is almost always dosing frequency, the timing between doses, and the specific protocol that matches their formulation type
Jastreboff AM, Aronne LJ, Ahmad NN, et al
In the ATTAIN-MAINTAIN trial, 205 patients taking tirzepatide and 171 patients taking semaglutide were randomized to take orforglipron or placebo (no active drug) daily for a year
doi: 10.3389/fendo.2022.846903 Received 31 December 2021 Accepted 01 February 2022 Published 21 February 2022 Volume 13 - 2022 Edited by Paolo Moghetti, University of Verona, Italy Reviewed by Flavia Prodam, University of Eastern Piedmont, Italy Updates Copyright 2022 Cignarelli, Genchi, Le Grazie, Caruso, Marrano, Biondi, DOria, Sorice, Natalicchio, Perrini, Laviola and Giorgino
Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)
The normal endocrine cell of the gut: changing concepts and new evidences
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