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Reintroduction of SYNCRIP into KO cells reversed this phenotype, indicating that SYNCRIP is critical for maintaining redox homeostasis in GBM (Figures 2B and S2B)

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Additionally, a cross-sectional study of 1,105 community-dwelling elderly individuals found that higher physiological melatonin levels were correlated with a lower prevalence of depressed mood and cognitive impairment, independent of depressive symptoms [220]

Maddiboyina et al., 2023)