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Studies have shown that resveratrol treatment reduces the proportion of tumor-promoting M2 tumor-associated macrophages (TAM) in tumor tissues and significantly enhances the activation of tumor-infiltrating CD8+ T cells ( Polyphenols exert multitargeted anticancer effects through modulation of key signaling pathways

Both SPT and DES1 are required for ceramide biosynthesis

Figure 2 shows the chemical structures of major flavonoids with hepatoprotective effects

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