Rather than focusing solely on therapeutic efficacy, this work integrates material design, localized drug delivery, and biological evaluation to explore a rectally administered strategy aimed at enhancing local radioprotection while minimizing systemic exposure
27 Cellular metabolism is completely reprogrammed during tumorigenesis, resulting in deregulation of AMPK signaling
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A notable research effort, known as the STEP (Semaglutide GLP-1 Treatment Effect in People with Obesity) trial, revealed that participants taking Semaglutide GLP-1 achieved an average weight reduction of around 15% of their starting body weight within 68 weeks, unlike those taking a placebo
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Simultaneously, ferrous iron (Fe 2+ ) reacts with hydrogen peroxide (H 2 O 2 ) via the Fenton reaction to generate highly reactive hydroxyl radicals (OH), which further propagate lipid peroxidation
