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A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth

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This makes it useful in managing vasoplegic syndrome , septic shock , and anaphylaxis , where conventional vasopressors may fail

It has also been reported that when lactate is elevated beyond anaerobic threshold, which is associated with greater demands on anaerobic glycolysis, the hypothalamus is highly stimulated (Kraemer et al., 1990, 1993